| Weight | 331.413 g/mol |
|---|---|
| Formula | C15H29N3O5 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 5 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 7 |
Marimastat (154039-60-8)
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- A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer (British Journal of Cancer, 2002)
- Marimastat as First-Line Therapy for Patients With Unresectable Pancreatic Cancer: A Randomized Trial (Journal of Clinical Oncology, 2001)
- Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. (Pharmacology & Therapeutics, 1997)
- Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Marimastat After Response to First-Line Chemotherapy in Patients With Small-Cell Lung Cancer: A Trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer (Journal of Clinical Oncology, 2002)
- Phase I trial of Marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer. (Journal of Clinical Oncology, 1998)
- Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies. (Clinical Cancer Research, 1998)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCC(C)CC(C(C(=O)NO)O)C(=O)NC(C(=O)NC)C(C)(C)C
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- Pubchem - Marimastat
- Wikipedia - marimastat
Marimastat was a proposed antineoplastic drug developed by British Biotech. It acted as a broad-spectrum matrix metalloproteinase inhibitor. Marimastat performed poorly in clinical trials, and development was terminated.
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Synthesis
AC1L9JYI
+
Reactant
(Alkylation of primary amines)
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