| Weight | 236.278 g/mol |
|---|---|
| Formula | C5H8N4O3S2 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
methazolamide (554-57-4, 1164547-86-7)
N-Methylacetazolamide · N Methylacetazolamide
Score:
#1997 in Biology
,
#2436 in Chemistry
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- Sigma-Aldrich - methazolamide98.90 - 338.10 USD
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- The pharmacology of methazolamide in relation to the treatment of glaucoma. (Investigative Ophthalmology & Visual Science, 1977)
- Methazolamide and Melatonin Inhibit Mitochondrial Cytochrome C Release and Are Neuroprotective in Experimental Models of Ischemic Injury (Stroke, 2009)
- Effect of bicarbonate, pH, methazolamide and stilbenes on the intracellular potentials of cultured bovine corneal endothelial cells. (The Journal of Membrane Biology, 1984)
- Stevens-Johnson syndrome induced by methazolamide treatment (Archives of Ophthalmology, 1997)
- Effect of Methazolamide on Chronic Macular Edema in Patients with Retinitis Pigmentosa (Ophthalmology, 1994)
- HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (Pharmacogenomics, 2010)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - N-Methylacetazolamide
- N Methylacetazolamide
-
SMILESCC(=O)N=C1N(N=C(S1)S(=O)(=O)N)C
-
InChIKeyFLOSMHQXBMRNHR-UHFFFAOYSA-N
- Pubchem - methazolamide
- Wikipedia - methazolamide
Methazolamide (trade name Neptazane) is a potent carbonic anhydrase inhibitor. It is indicated in the treatment of increased intraocular pressure (IOP) in chronic open-angle glaucoma and secondary glaucoma. Also it is used preoperatively in acute angle-closure (narrow-angle) glaucoma where lowering the IOP is desired before surgery.
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Synthesis
ACETYL CHLORIDE
+
5-imino-4-methyl-1,3,4-thiadiazole-2-sulfonamide
(Schotten-Baumann amide from acid)
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methazolamide
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