| Weight | 309.406 g/mol |
|---|---|
| Formula | C17H27NO4 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 7 |
Metipranolol (22664-55-7)
Trimepranol · Methypranol · Disorat
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- Design of New Formulations for Topical Ocular Administration: Polymeric Nanocapsules Containing Metipranolol (Pharmaceutical Research, 1993)
- The -adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol (Experimental Eye Research, 2003)
- Metipranolol-associated granulomatous anterior uveitis. (British Journal of Ophthalmology, 1991)
- Metipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: a comparison with other anti-glaucoma drugs. (Investigative Ophthalmology & Visual Science, 2004)
- Metipranolol-associated Granulomatous Iritis (American Journal of Ophthalmology, 1994)
- Levobunolol and metipranolol: comparative ocular hypotensive efficacy, safety, and comfort. (British Journal of Ophthalmology, 1987)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Trimepranol
- Methypranol
- Disorat
- 1-(4-Acetoxy-2,3,5-Trimethylphenoxy)-3-Isopropylamino-2-Propanol
-
SMILESCC1=CC(=C(C(=C1OC(=O)C)C)C)OCC(CNC(C)C)O
-
InChIKeyBQIPXWYNLPYNHW-UHFFFAOYSA-N
- Pubchem - Metipranolol
- Wikipedia - metipranolol
Metipranolol (OptiPranolol, Betanol, Disorat, Trimepranol) is a non-selective beta blocker used in eye drops to treat glaucoma. It is rapidly metabolized into desacetylmetipranolol.
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Synthesis
ISOPROPYLAMINE
+
Reactant
(Alkylation of primary amines)
4-Hydroxy-2,3,6-trimethylphenyl acetate
+
Reactant
(Williamson ether)
Reactant
+
CID 5475562
(Chan-Lam coupling reaction)
Reactant
+
PERACETIC ACID
(Dakin oxidation)
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
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Metipranolol
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