| Weight | 206.289 g/mol |
|---|---|
| Formula | C12H18N2O |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 2 |
Oxotremorine (70-22-4)
Oxytremorine
Score:
#279 in Neuroscience
,
#1282 in Biology
,
#1487 in Chemistry
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- The effect of oxotremorine and atropine on cGMP and cAMP levels in mouse cerebral cortex and cerebellum (Biochemical and Biophysical Research Communications, 1970)
- THE PERIPHERAL ACTIONS OF OXOTREMORINE, A METABOLITE OF TREMORINE (Journal of Pharmacology and Experimental Therapeutics, 1962)
- Differential Stimulation of Inositol Phospholipid Turnover in Brain by Analogs of Oxotremorine (Journal of Neurochemistry, 1984)
- Depression of Acetylcholine Release from Cerebral Cortical Slices by Cholinesterase Inhibition and by Oxotremorine (Nature, 1973)
- Hypothermia following systematic and intracerebral injection of oxotremorine in the rat (Neuropharmacology, 1966)
- Memory facilitation with posttrial injection of oxotremorine and physostigmine in mice. (Psychopharmacology, 1979)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Oxytremorine
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SMILESC1CCN(C1)CC#CCN2CCCC2=O
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InChIKeyRSDOPYMFZBJHRL-UHFFFAOYSA-N
- Pubchem - Oxotremorine
- Wikipedia - oxotremorine
Oxotremorine is a parasympathomimetic drug that acts as a selective muscarinic acetylcholine receptor agonist. Oxotremorine produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental studies aimed at determining more effective anti-Parkinsonian drugs. Oxotremorine produces also antipsychotic effects.
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Synthesis
Reactant
+
1-(prop-2-yn-1-yl)pyrrolidine
(Sonogashira)
Reactant
+
2-Pyrrolidinone
(Chan-Lam coupling reaction)
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