| Weight | 325.372 g/mol |
|---|---|
| Formula | C17H19N5O2 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 6 |
Pixantrone (144510-96-3, 144675-97-8)
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- Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial (Lancet Oncology, 2012)
- Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: Comparative studies against doxorubicin and mitoxantrone (Investigational New Drugs, 2006)
- The Novel Anthracenedione, Pixantrone, Lacks Redox Activity and Inhibits Doxorubicinol Formation in Human Myocardium: Insight to Explain the Cardiac Safety of Pixantrone in Doxorubicin-Treated Patients (Journal of Pharmacology and Experimental Therapeutics, 2013)
- Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent (Nucleic Acids Research, 2007)
- Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity (Journal of the Neurological Sciences, 2004)
- Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitis (Journal of Neuroimmunology, 2004)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC(=C2C(=C1NCCN)C(=O)C3=C(C2=O)C=NC=C3)NCCN
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InChIKeyPEZPMAYDXJQYRV-UHFFFAOYSA-N
- Pubchem - Pixantrone
- Wikipedia - pixantrone dimaleate
Pixantrone (rINN; trade name Pixuvri) is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue. It acts as a topoisomerase II poison and intercalating agent. The code name BBR 2778 refers to pixantrone dimaleate, the actual substance commonly used in clinical trials.
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