| Weight | 646.744 g/mol |
|---|---|
| Formula | C38H38N4O6 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 11 |
Tariquidar (206873-63-4)
Score:
#28 in Medicinal chemistry
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#1060 in Neuroscience
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#4602 in Biology
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#5833 in Chemistry
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- Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance (Journal of Controlled Release, 2009)
- Phase II study of tariquidar, a selective Pglycoprotein inhibitor, in patients with chemotherapyresistant, advanced breast carcinoma (Cancer, 2005)
- Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor. (Expert Review of Anticancer Therapy, 2007)
- Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes. (International Journal of Pharmaceutics, 2011)
- Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from the p-Glycoprotein (ABCB1) Modulator Tariquidar (Journal of Medicinal Chemistry, 2009)
- The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). (ACS Chemical Neuroscience, 2011)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCOC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC
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InChIKeyLGGHDPFKSSRQNS-UHFFFAOYSA-N
- Pubchem - Tariquidar
- Wikipedia - tariquidar
Tariquidar (INN/USAN) is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer.
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Tariquidar
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