| Weight | 248.717 g/mol |
|---|---|
| Formula | C12H13ClN4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
pyrimethamine (58-14-0)
Daraprim · Malocide · Tindurine
Score:
#58 in Microbiology
,
#768 in Biology
,
#843 in Chemistry
"What do you need help with?"
LabBot
- Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. (American Journal of Tropical Medicine and Hygiene, 1995)
- EVIDENCE THAT A POINT MUTATION IN DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE CONFERS RESISTANCE TO PYRIMETHAMINE IN FALCIPARUM MALARIA (Proceedings of the National Academy of Sciences of the United States of America, 1988)
- Molecular Markers for Failure of Sulfadoxine-Pyrimethamine and Chlorproguanil-Dapsone Treatment of Plasmodium falciparum Malaria (The Journal of Infectious Diseases, 2002)
- Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum (Proceedings of the National Academy of Sciences of the United States of America, 1988)
- Efficacy of sulfadoxine-pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. (American Journal of Tropical Medicine and Hygiene, 1998)
- Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropteroate Synthase and Epidemiologic Patterns of Pyrimethamine-Sulfadoxine Use and Resistance (The Journal of Infectious Diseases, 1997)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Daraprim
- Malocide
- Tindurine
- Glaxo Wellcome Brand of Pyrimethamine
- Aventis Brand of Pyrimethamine
- Chloridin
- GlaxoSmithKline Brand of Pyrimethamine
- Wellcome Brand of Pyrimethamine
-
SMILESCCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
-
InChIKeyWKSAUQYGYAYLPV-UHFFFAOYSA-N
- Pubchem - pyrimethamine
- Wikipedia - pyrimethamine
Pyrimethamine, sold under the trade name Daraprim, is a medication used with leucovorin to treat toxoplasmosis and cystoisosporiasis. It is also used with dapsone as a second line option to prevent Pneumocystis jiroveci pneumonia (PCP) in people with HIV/AIDS. It was previously used for malaria but is no longer recommended due to resistance.
Suppliers
Most-cited Publications
Areas of Application
Safety
Trends
Alternate Names
External Links
Synthesis
Reactant
+
1,4-DICHLOROBENZENE
(Decarboxylative coupling)
Similar Compounds
2,5-dimethyl-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
(428845-73-2)
9 alternate names
3 suppliers
5-phenylpyrimidin-4-amine
(21419-05-6)
9 alternate names
3 suppliers
5-(4-fluorophenyl)pyrimidin-4-amine
(56239-05-5)
9 alternate names
3 suppliers
4-TERT-BUTYL-6-PHENYL-2-PYRIMIDINAMINE
(313505-80-5)
9 alternate names
3 suppliers
3-ethyl-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-amine
(956268-27-2)
9 alternate names
3 suppliers
199864-87-4
(199864-87-4)
9 alternate names
3 suppliers
5,6,7,8-Tetrahydroquinazoline-2,4-diamine
(1899-40-7)
9 alternate names
3 suppliers
3-Methyl-4-phenyl-1H-pyrazol-5-amine
(31924-81-9)
9 alternate names
3 suppliers
3-ETHYL-4-(4-FLUOROPHENYL)ISOXAZOL-5-AMINE
(915923-98-7)
9 alternate names
3 suppliers
4-(4-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine
(1015846-18-0)
9 alternate names
3 suppliers
4-(2-methoxyphenyl)-1,3-dimethyl-1H-pyrazol-5-amine
(1015845-78-9)
9 alternate names
3 suppliers
1,3-dimethyl-4-phenyl-1H-pyrazol-5-amine
(3654-22-6)
9 alternate names
3 suppliers
4-(4-chlorophenyl)-3-methyl-5-isoxazolamine
(98947-25-2)
9 alternate names
3 suppliers
219580-11-7
(219580-11-7)
9 alternate names
3 suppliers
4-methyl-6-phenylpyrimidin-2-amine
(15755-15-4)
9 alternate names
3 suppliers
2829-59-6
(2829-59-6)
9 alternate names
3 suppliers
4-(4-chlorophenyl)-1H-pyrazol-5-amine
(40545-65-1)
9 alternate names
3 suppliers
oxo(2-phenyl-3-indolizinyl)acetic acid
(892691-05-3)
9 alternate names
3 suppliers
26974-09-4
(26974-09-4)
9 alternate names
3 suppliers
2-(4-hydrazino-6-methylpyrimidin-2-yl)phenol
(300358-31-0)
9 alternate names
3 suppliers
4-(4-Methoxyphenyl)-3-methylisoxazol-5-amine
(902835-79-4)
9 alternate names
3 suppliers
6-ethyl-2-methylpyrimidin-4-amine
(90008-43-8)
9 alternate names
3 suppliers
Etriciguat
(402595-29-3)
9 alternate names
3 suppliers
6-Ethylpyrimidin-4-amine
(856160-67-3)
9 alternate names
3 suppliers
4-methyl-6-(1-piperazinyl)-2-pyrimidinamine
(32705-71-8)
9 alternate names
3 suppliers
3435-27-6
(3435-27-6)
9 alternate names
3 suppliers
6-ISOPROPYLPYRIMIDIN-4-AMINE
(1159818-06-0)
9 alternate names
3 suppliers
82588-41-8
(82588-41-8)
9 alternate names
3 suppliers
3-methyl-4-phenylisoxazol-5-amine
(4416-71-1)
9 alternate names
3 suppliers
5-chloro-3-phenyl-1H-indole-2-carboxylic acid
(21139-31-1)
9 alternate names
3 suppliers
2-Amino-4-piperidino-6-methylpyrimidine
(91717-22-5)
9 alternate names
3 suppliers
5,6-DIMETHYL-4-PHENYL-2-PYRIDINAMINE
(1123169-34-5)
9 alternate names
3 suppliers
4,5-dihydronaphtho[2,1-d][1,3]thiazol-2-amine
(401622-74-0)
9 alternate names
3 suppliers
2-[(5-PHENYL-2-PYRIMIDINYL)AMINO]ETHANOL
(298217-37-5)
9 alternate names
3 suppliers
1,2,3,7,8,9-hexahydrocyclopenta[d]cyclopenta[3,4]pyrazolo[1,5-a]pyrimidin-6-amine
(878417-21-1)
9 alternate names
3 suppliers
6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
(26979-06-6)
9 alternate names
3 suppliers
ATORVASTATIN CALCIUM
(110862-48-1, 134523-03-8)
9 alternate names
3 suppliers
4-(3-chlorophenyl)-1H-pyrazol-5-amine
(95750-97-3)
9 alternate names
3 suppliers
4-(4-Fluorophenyl)-3-methylisoxazol-5-amine
(915919-94-7)
9 alternate names
3 suppliers
2-Chloro-N-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
(76780-98-8)
9 alternate names
3 suppliers
(1-methyl-5-nitro-3-phenyl-1H-indol-2-yl)methanol
(89159-60-4)
9 alternate names
3 suppliers
Fendosal
(53597-27-6)
9 alternate names
3 suppliers
mofezolac
(78967-07-4)
9 alternate names
3 suppliers
ethyl 5-chloro-3-phenyl-1H-indole-2-carboxylate
(21139-32-2)
9 alternate names
3 suppliers
4-phenyl-6-pyrrolidin-1-ylpyrimidin-2-amine
(424810-78-6)
9 alternate names
3 suppliers
Sodium (S)-4-carboxy-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)butanoate
(15475-56-6)
9 alternate names
3 suppliers
2-chloro-6-methyl-5-phenylnicotinonitrile
(10176-63-3)
9 alternate names
3 suppliers
2-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one
(21599-37-1)
9 alternate names
3 suppliers
2-phenylimidazo[1,2-a]pyrimidine-3-carbaldehyde
(74944-29-9)
9 alternate names
3 suppliers
5,6,7,8-tetrahydroquinazolin-2-amine
(2305-85-3)
9 alternate names
3 suppliers
4-(3,4-dimethoxyphenyl)-1H-pyrazol-5-amine
(278600-50-3)
9 alternate names
3 suppliers
96323-20-5
(96323-20-5)
9 alternate names
3 suppliers
4-(4-ethoxyphenyl)-1H-pyrazol-5-amine
(1040454-88-3)
9 alternate names
3 suppliers
3-phenylquinoline-2,4-dicarboxylic acid
(19585-90-1)
9 alternate names
3 suppliers
4-chloro-N,N-dimethyl-5,6,7,8-tetrahydroquinazolin-2-amine
(71406-81-0)
9 alternate names
3 suppliers
4-ethyl-6-(1-piperazinyl)pyrimidine dihydrochloride hydrate
(153469-07-9)
9 alternate names
3 suppliers
4-(4-methoxyphenyl)-1H-pyrazol-5-amine
(93439-79-3)
9 alternate names
3 suppliers
5,6-Diphenylfuro[2,3-d]pyrimidin-4-amine
(5207-52-3)
9 alternate names
3 suppliers
2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-amine
(80493-71-6)
9 alternate names
3 suppliers
ethyl 5-methoxy-3-phenyl-1H-indole-2-carboxylate
(27294-08-2)
9 alternate names
3 suppliers
5-Nitro-3-phenyl-1H-indole-2-carboxylic acid
(14182-37-7)
9 alternate names
3 suppliers
Bleomycin sulfate
(11056-06-7, 9041-93-4)
9 alternate names
3 suppliers
SULFISOMIDINE
(515-64-0)
9 alternate names
3 suppliers
85811-56-9
(85811-56-9)
9 alternate names
3 suppliers
6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-amine
(108990-72-3)
9 alternate names
3 suppliers
113246-86-9
(113246-86-9)
9 alternate names
3 suppliers
4-chloro-6-ethyl-2-piperidin-1-ylpyrimidine
(901586-58-1)
9 alternate names
3 suppliers
5-ethyl-4-methyl-6-(1-piperidinyl)-2-pyrimidinamine
(915920-63-7)
9 alternate names
3 suppliers
209409-98-3
(209409-98-3)
9 alternate names
3 suppliers
4-(3-methoxyphenyl)-1H-pyrazol-5-amine hydrochloride
(93690-16-5)
9 alternate names
3 suppliers
5-ethyl-4-methyl-6-(1-pyrrolidinyl)-2-pyrimidinamine
(424803-29-2)
9 alternate names
3 suppliers
4-chloro-6-ethyl-N,N-dimethylpyrimidin-2-amine
(71406-66-1)
9 alternate names
3 suppliers
Puromycin hydrochloride
(58-58-2)
9 alternate names
3 suppliers
4-(4-chlorophenyl)pyrimidin-2-amine
(133256-51-6)
9 alternate names
3 suppliers
4-(4-chlorophenyl)-1H-pyrrole-3-carboxylic Acid
(122453-98-9)
9 alternate names
3 suppliers
4-methyl-5,6,7,8-tetrahydroquinazolin-2-amine
(58544-43-7)
9 alternate names
3 suppliers
2-hydrazino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidine
(1410821-11-2)
9 alternate names
3 suppliers
ethyl 2-phenylimidazo[1,2-a]pyridine-3-carboxylate
(119448-82-7)
9 alternate names
3 suppliers
coelenterazine
(55779-48-1)
9 alternate names
3 suppliers
Cyanocobalamine
(68-19-9)
9 alternate names
3 suppliers
vitamin B12
(13408-78-1, 68-19-9)
9 alternate names
3 suppliers
5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine
(87119-67-3)
9 alternate names
3 suppliers
49779-99-9
(49779-99-9)
9 alternate names
3 suppliers
2-(4-bromophenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine
(310422-24-3)
9 alternate names
3 suppliers
95611-88-4
(95611-88-4)
9 alternate names
3 suppliers
4-(trifluoromethyl)-5,6,7,8-tetrahydroquinazolin-2-amine
(256954-38-8)
9 alternate names
3 suppliers
6-Biphenyl-4-yl-imidazo[2,1-b]thiazole-5-carbaldehyde
(82588-43-0)
9 alternate names
3 suppliers
91182-87-5
(91182-87-5)
9 alternate names
3 suppliers
pyrimethamine
CAS Directory
