| Weight | 275.348 g/mol |
|---|---|
| Formula | C16H21NO3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 4 |
rolipram (61413-54-5)
ZK 62711 · ZK62711 · ZK-62711
Score:
#867 in Neuroscience
,
#1700 in Biochemistry
,
#3789 in Biology
,
#4770 in Chemistry
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- Sigma-Aldrich - rolipram128.00 - 922.00 USD
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- TCI - rolipram121.00 - 424.00 USD
- Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory (Proceedings of the National Academy of Sciences of the United States of America, 1998)
- Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment (Journal of Clinical Investigation, 2004)
- The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis (Nature Medicine, 1995)
- The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery (Proceedings of the National Academy of Sciences of the United States of America, 2004)
- Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors (Neuropharmacology, 1983)
- 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain (Molecular Pharmacology, 1976)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - ZK 62711
- ZK62711
- ZK-62711
-
SMILESCOC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
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InChIKeyHJORMJIFDVBMOB-UHFFFAOYSA-N
- Pubchem - rolipram
- Wikipedia - rolipram
Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It served as a prototype molecule for several companies' drug discovery and development efforts. Rolipram was discontinued after clinical trials showed that its therapeutic window was too narrow; it could not be dosed at high enough levels to be effective without causing significant gastrointestinal side effects.
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rolipram
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