| Weight | 375.559 g/mol |
|---|---|
| Formula | C20H25NO2S2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 6 |
tiagabine (115103-54-3)
Score:
#67 in Neurology
,
#340 in Neuroscience
,
#1542 in Biology
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- Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. (European Journal of Pharmacology, 1994)
- A Review of the Preclinical Pharmacology of Tiagabine: A Potent and Selective Anticonvulsant GABA Uptake Inhibitor (Epilepsia, 1995)
- Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures (Journal of Neurophysiology, 1992)
- Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. (European Journal of Pharmacology, 1991)
- The -aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats (European Journal of Pharmacology, 1992)
- Comparison of Antiepileptic Drugs Tiagabine, Lamotrigine, and Gabapentin in Mouse Models of Acute, Prolonged, and Chronic Nociception (Journal of Pharmacology and Experimental Therapeutics, 2002)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C
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- Pubchem - tiagabine
- Wikipedia - tiagabine
Tiagabine (trade name Gabitril) is an anticonvulsant medication used in the treatment of epilepsy that is produced by Cephalon. The drug is also used off-label in the treatment of anxiety disorders and panic disorder.
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