| Weight | 319.191 g/mol |
|---|---|
| Formula | C16H12Cl2N2O |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 1 |
4'-Chlorodiazepam (14439-61-3)
Ro 5-4864 · chlordiazepam · Ro5-4864
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- Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro 5-4864. (Molecular Pharmacology, 1982)
- Specific high-affinity binding sites for [3H]Ro 5-4864 in rat brain and kidney. (Journal of Pharmacology and Experimental Therapeutics, 1983)
- Binding of [3H]Ro 5?4864 and [3H]PK 11195 to Cerebral Cortex and Peripheral Tissues of Various Species: Species Differences and Heterogeneity in Peripheral Benzodiazepine Binding Sites (Journal of Neurochemistry, 1987)
- Isolation and Characterization of a Rat Brain Triakontatetraneuropeptide, a Posttranslational Product of Diazepam Binding Inhibitor: Specific Action at the Ro 54864 Recognition Site (Journal of Neurochemistry, 1989)
- Inescapable shock reduces [3H]Ro 5-4864 binding to peripheral-type benzodiazepine receptors in the rat (Pharmacology, Biochemistry and Behavior, 1986)
- Behavioural actions of Ro 5-4864: A peripheral-type benzodiazepine? (Life Sciences, 1984)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Ro 5-4864
- chlordiazepam
- Ro5-4864
- Ro-05-4864
-
SMILESCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=C(C=C3)Cl
-
InChIKeyPUMYFTJOWAJIKF-UHFFFAOYSA-N
- Pubchem - 4'-Chlorodiazepam
- Wikipedia - chlordiazepam
Ro5-4864 (4'-chlorodiazepam) is a drug which is a benzodiazepine derivative of diazepam. However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABAA receptors and lacks typical benzodiazepine effects, instead being sedative yet also convulsant and anxiogenic in effects. Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor", later renamed to mitochondrial translocator protein 18kDa (TSPO).
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