| Weight | 436.961 g/mol |
|---|---|
| Formula | C21H25ClN2O4S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 8 |
Tianeptine
Ardix brand of tianeptine, monosodium salt · tianeptine, monosodium salt, (+-)-isomer · (3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2)thiazepin-11-yl)-7-aminoheptanoic acid
169293-31-6, 191172-75-5, 72797-41-2, 66981-73-5
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#816 in Neuroscience
,
#3577 in Biology
,
#4490 in Chemistry
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- Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine (Proceedings of the National Academy of Sciences of the United States of America, 2001)
- Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment (Behavioral Neuroscience, 1996)
- Tianeptine attenuates stress-induced morphological changes in the hippocampus (European Journal of Pharmacology, 1992)
- The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine (Biological Psychiatry, 2004)
- Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine (Proceedings of the National Academy of Sciences of the United States of America, 2004)
- Tianeptine, a selective enhancer of serotonin uptake in rat brain (Naunyn-schmiedebergs Archives of Pharmacology, 1987)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Ardix brand of tianeptine, monosodium salt
- tianeptine, monosodium salt, (+-)-isomer
- (3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2)thiazepin-11-yl)-7-aminoheptanoic acid
- tianeptine, (+-)-isomer
- coaxil
- Stablon
- tianeptine, monosodium salt
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SMILESCN1C2=CC=CC=C2C(C3=C(S1(=O)=O)C=C(C=C3)Cl)NCCCCCCC(=O)O
-
InChIKeyJICJBGPOMZQUBB-UHFFFAOYSA-N
- Pubchem - Tianeptine
- Wikipedia - tianeptine
Tianeptine, sold under the brand names Stablon and Coaxil among others, is an atypical antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. In terms of chemical structure, it is technically a tricyclic antidepressant (TCA), but it has a very different drug profile than other TCAs, and is not usually grouped with them. Tianeptine has antidepressant and anxiolytic effects with a relative lack of sedative, anticholinergic, and cardiovascular side effects.
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