| Weight | 331.176 g/mol |
|---|---|
| Formula | C13H8Cl2O4S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Ticrynafen (40180-04-9)
Tienilic Acid · Selacryn · ANP 3624
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- A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis. (Clinical and Experimental Immunology, 1984)
- Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: Inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid (Biochemistry, 1994)
- Ticrynafen-associated hepatic injury: analysis of 340 cases. (Hepatology, 1984)
- Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity : comparison with two directly hepatotoxic drugs (Chemical Research in Toxicology, 1994)
- The substrate binding site of human liver cytochrome P450 2C9: an approach using designed tienilic acid derivatives and molecular modeling. (Biochemistry, 1995)
- Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9. (Molecular Pharmacology, 1996)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Tienilic Acid
- Selacryn
- ANP 3624
- SKF 62698
- SKF62698
- SKF-62698
- ANP-3624
- ANP3624
- Thienylic Acid
-
SMILESC1=CSC(=C1)C(=O)C2=C(C(=C(C=C2)OCC(=O)O)Cl)Cl
-
InChIKeyAGHANLSBXUWXTB-UHFFFAOYSA-N
- Pubchem - Ticrynafen
- Wikipedia - ticrynafen
Tienilic acid (INN and BAN) or ticrynafen (USAN) is a loop diuretic drug with uric acid-lowering (uricosuric) action, formerly marketed for the treatment of hypertension. It was approved by FDA on May 2, 1979, and withdrawn in 1982, after case reports in the United States indicated a link between the use of ticrynafen and hepatitis. Criminal charges were brought against SmithKline executives with regard to hiding data related to toxicity while gaining FDA approval.
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Ticrynafen
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