| Weight | 227.735 g/mol |
|---|---|
| Formula | C12H18ClNO |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
tulobuterol (41570-61-0)
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- The pharmacokinetics of the 2-adrenoceptor agonist, tulobuterol, given transdermally and by inhalation (European Journal of Clinical Pharmacology, 1993)
- Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease. (Pulmonary Pharmacology & Therapeutics, 2008)
- Alteration of the Circadian Rhythm in Peak Expiratory Flow of Nocturnal Asthma Following Nighttime Transdermal 2adrenoceptor Agonist Tulobuterol Chronotherapy (Chronobiology International, 2005)
- Transdermal therapeutic system containing tulobuterol hydrochloride for administering the bronchodilator tulobuterol via the skin (2000)
- Effect of porous silica on sustained release behaviors of pH sensitive pluronic F127/poly(acrylic acid) hydrogels containing tulobuterol. (Colloids and Surfaces B: Biointerfaces, 2010)
- Effects of sustained-release tulobuterol on asthma control and beta-adrenoceptor function. (Clinical and Experimental Pharmacology and Physiology, 2002)
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SMILESCC(C)(C)NCC(C1=CC=CC=C1Cl)O
-
InChIKeyYREYLAVBNPACJM-UHFFFAOYSA-N
- Pubchem - tulobuterol
- Wikipedia - tulobuterol
Tulobuterol (INN) is a long-acting beta2-adrenergic receptor agonist, marketed in Japan as a transdermal patch under the name Hokunalin tape (). Currently, it is only legal in 7 countries: Japan, Germany, China, South Korea, Bangladesh, Pakistan, and Venezuela.
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Synthesis
Reactant
+
1,2-DICHLOROBENZENE
(Grignard alcohol)
Reactant
+
tert-Butylamine
(Reductive amination)
CHLOROBENZENE
+
Reactant
(Friedel-Crafts alkylation)
Tert-butylboronic Acid
+
Reactant
(Chan-Lam coupling reaction)
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