| Weight | 211.268 g/mol |
|---|---|
| Formula | C13H13N3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 0 |
Varenicline (249296-44-4)
Score:
#287 in Neuroscience
,
#1310 in Biology
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- Efficacy of Varenicline, an 42 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation A Randomized Controlled Trial (JAMA, 2006)
- Varenicline, an 42 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation A Randomized Controlled Trial (JAMA, 2006)
- Varenicline: An 42 Nicotinic Receptor Partial Agonist for Smoking Cessation (Journal of Medicinal Chemistry, 2005)
- Effect of maintenance therapy with varenicline on smoking cessation: a randomized controlled trial. (JAMA, 2006)
- Varenicline Is a Partial Agonist at 42 and a Full Agonist at 7 Neuronal Nicotinic Receptors (Molecular Pharmacology, 2006)
- Pharmacological profile of the 42 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid (Neuropharmacology, 2007)
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SMILESC1C2CNCC1C3=CC4=NC=CN=C4C=C23
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- Pubchem - Varenicline
- Wikipedia - Varenicline
Varenicline (trade name Chantix and Champix), is a prescription medication used to treat nicotine addiction. It both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. It is a high-affinity partial agonist for the 42 nicotinic acetylcholine receptor subtype (nACH) that leads to the release of dopamine in the nucleus accumbens when activated, and therefore, has the capacity to reduce the feelings of craving and withdrawal caused by smoking cessation.
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