| Weight | 167.128 g/mol |
|---|---|
| Formula | C5H5N5O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 0 |
8-Hydroxyguanine (5614-64-2)
oxo-8-Gua · 2-amino-6,8-dihydroxypurine · 8-oxoguanine
Score:
#1307 in Biochemistry
,
#3201 in Biology
,
#4003 in Chemistry
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- 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. (Journal of Biological Chemistry, 1992)
- Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. (Carcinogenesis, 1986)
- The role of 8-hydroxyguanine in carcinogenesis (Carcinogenesis, 1990)
- Oxidative DNA damage in the Parkinsonian brain : An apparent selective increase in 8-hydroxyguanine levels in substantia nigra (Journal of Neurochemistry, 2002)
- Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. (Biochemistry, 1990)
- The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine). (Journal of Bacteriology, 1992)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - oxo-8-Gua
- 2-amino-6,8-dihydroxypurine
- 8-oxoguanine
- 8-oxo-7,8-dihydroguanine
-
SMILESC12=C(NC(=NC1=O)N)NC(=O)N2
-
InChIKeyCLGFIVUFZRGQRP-UHFFFAOYSA-N
- Pubchem - 8-Hydroxyguanine
- Wikipedia - 8-oxoguanine
8-Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OH8Gua) is one of the most common DNA lesions resulting from reactive oxygen species and can result in a mismatched pairing with adenine resulting in G to T and C to A substitutions in the genome. In humans, it is primarily repaired by DNA glycosylase OGG1. It can be caused by ionizing radiation, in connection with oxidative metabolism.
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