| Weight | 241.254 g/mol |
|---|---|
| Formula | C12H11N5O |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 3 |
o6-benzylguanine (19916-73-5)
O(6)-bGua · O(6)-benzylguanine · 6-O-benzylguanine
Score:
#2544 in Biochemistry
,
#6334 in Chemistry
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- Sigma-Aldrich - o6-benzylguanine78.20 USD
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- Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. (Proceedings of the National Academy of Sciences of the United States of America, 1990)
- Phase I Trial of Temozolomide Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma (Journal of Clinical Oncology, 2000)
- Effect of O6-Benzylguanine Analogues on Sensitivity of Human Tumor Cells to the Cytotoxic Effects of Alkylating Agents (Cancer Research, 1991)
- O6-benzylguanine and its role in chemotherapy (Clinical Cancer Research, 1997)
- Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma. (Journal of Clinical Oncology, 1998)
- Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea. (Biochemistry, 1996)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - O(6)-bGua
- O(6)-benzylguanine
- 6-O-benzylguanine
-
SMILESC1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N
-
InChIKeyKRWMERLEINMZFT-UHFFFAOYSA-N
- Pubchem - o6-benzylguanine
- Wikipedia - 6-O-benzylguanine
O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as an suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair.
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o6-benzylguanine
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