| Weight | 354.458 g/mol |
|---|---|
| Formula | C19H26N6O |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 8 |
roscovitine (186692-46-6)
Score:
#1766 in Biochemistry
,
#3879 in Biology
,
#4886 in Chemistry
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- Sigma-Aldrich - roscovitine81.70 - 283.00 USD
- Fisher Scientific - Search for roscovitine
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- Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the CyclinDependent Kinases cdc2, cdk2 and cdk5 (FEBS Journal, 1997)
- Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. (FEBS Journal, 1997)
- IN VITRO AND IN VIVO ANTITUMOR PROPERTIES OF THE CYCLIN DEPENDENT KINASE INHIBITOR CYC202 (R-ROSCOVITINE) (International Journal of Cancer, 2002)
- Roscovitine targets, protein kinases and pyridoxal kinase. (Journal of Biological Chemistry, 2005)
- Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials (Accounts of Chemical Research, 2003)
- Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine (Nature, 2006)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
-
InChIKeyBTIHMVBBUGXLCJ-UHFFFAOYSA-N
- Pubchem - roscovitine
- Wikipedia - seliciclib
Seliciclib (roscovitine or CYC202) is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9, which alter the growth phase or state within the cell cycle of treated cells. Seliciclib is being developed by Cyclacel. Seliciclib is being researched for the treatment of non-small cell lung cancer (NSCLC), Cushing's disease, leukemia, HIV infection, herpes simplex infection, cystic fibrosis and the mechanisms of chronic inflammation disorders.
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