| Weight | 283.306 g/mol |
|---|---|
| Formula | C16H14FN3O |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 2 |
afloqualone (56287-74-2)
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- Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. (Japanese Journal of Pharmacology, 1982)
- CHARACTERIZATION OF AFLOQUALONE N-GLUCURONIDATION: SPECIES DIFFERENCES AND IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ISOFORM(S) (Drug Metabolism and Disposition, 2004)
- Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (Afloqualone), a new centrally acting muscle relaxant (I). (Japanese Journal of Pharmacology, 1981)
- Photodynamic Deoxyribonucleic Acid (DNA) Strand Breaking Activities of Enoxacin and Afloqualone (Chemical & Pharmaceutical Bulletin, 1992)
- Effects of tizanidine, eperisone and afloqualone on feline dorsal horn neuronal responses to peripheral cutaneous noxious and innocuous stimuli (Neuropharmacology, 1989)
- Afloqualone photosensitivity: immunogenicity of afloqualone-photomodified epidermal cells. (Photochemistry and Photobiology, 1994)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=CC=CC=C1N2C(=NC3=C(C2=O)C=C(C=C3)N)CF
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InChIKeyVDOSWXIDETXFET-UHFFFAOYSA-N
- Pubchem - afloqualone
- Wikipedia - afloqualone
Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku. It has sedative and muscle-relaxant effects resulting from its agonist activity at the subtype of the GABAa receptor , and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.
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