| Weight | 338.213 g/mol |
|---|---|
| Formula | C9H15N4O8P |
| Hydrogen Acceptors | 9 |
| Hydrogen Donors | 6 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 5 |
AICA ribonucleotide (3031-94-5)
CAIR · AICAR · ZMP
Score:
#1558 in Biochemistry
,
#3593 in Biology
,
#4508 in Chemistry
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- Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR (American Journal of Physiology-heart and Circulatory Physiology, 1999)
- Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase (FEBS Letters, 1994)
- Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR (American Journal of Physiology-endocrinology and Metabolism, 2004)
- AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats (Diabetes, 2002)
- Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle (Diabetes, 2006)
- Long-Term AICAR Administration Reduces Metabolic Disturbances and Lowers Blood Pressure in Rats Displaying Features of the Insulin Resistance Syndrome (Diabetes, 2002)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - CAIR
- AICAR
- ZMP
- aminoimidazole carboxamide ribonucleotide
- 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide
- AICA ribonucleotide, (D-ribofuranosyl)-isomer
- 5-amino-4-imidazolecarboxamide ribofuranoside 5'-monophosphate
- AICAriboside 5'-monophosphate
- 4-carboxy-5-aminoimidazole ribotide
- Z-nucleotide
- 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide monophosphate
-
SMILESC1=NC(=C(N1C2C(C(C(O2)COP(=O)(O)O)O)O)N)C(=O)N
-
InChIKeyNOTGFIUVDGNKRI-UHFFFAOYSA-N
- Pubchem - AICA ribonucleotide
- Wikipedia - aicar
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has been used clinically to treat and protect against cardiac ischemic injury.
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AICA ribonucleotide
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