| Weight | 454.285 g/mol |
|---|---|
| Formula | C13H19N4O12P |
| Hydrogen Acceptors | 11 |
| Hydrogen Donors | 8 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 9 |
SAICAR (3031-95-6)
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- SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions (Science, 2012)
- SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells (Molecular Cell, 2014)
- The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis. (Structure, 1998)
- Structure of SAICAR synthase from Thermotoga maritima at 2.2 reveals an unusual covalent dimer (Acta Crystallographica Section F-structural Biology and Crystallization Communications, 2006)
- Molecular Dynamics Perspective on the Protein Thermal Stability: A Case Study Using SAICAR Synthetase (Journal of Chemical Information and Modeling, 2013)
- Two complementary radiometric methods for the measurement of 5-amino-4-imidazole-N-succinocarboxamide ribonucleotide synthetase (SAICAR synthetase) (Journal of Biochemical and Biophysical Methods, 1980)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=NC(=C(N1C2C(C(C(O2)COP(=O)(O)O)O)O)N)C(=O)NC(CC(=O)O)C(=O)O
-
InChIKeyNAQGHJTUZRHGAC-UHFFFAOYSA-N
- Pubchem - SAICAR
- Wikipedia - saicar
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) is an intermediate in the formation of purines. The conversion of ATP, L-aspartate, and 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide, ADP, and phosphate by phosphoribosylaminoimidazolesuccinocarboxamide synthetase (SAICAR synthetase) represents the eighth step of de novo purine nucleotide biosynthesis.
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