| Weight | 443.42 g/mol |
|---|---|
| Formula | C19H21N7O6 |
| Hydrogen Acceptors | 9 |
| Hydrogen Donors | 7 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 9 |
Dihydrofolic acid (4033-27-6)
Score:
#1568 in Biochemistry
,
#4523 in Chemistry
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- Sigma-Aldrich - Dihydrofolic acid86.50 - 643.00 USD
- Fisher Scientific - Search for Dihydrofolic acid
- TCI - Search for Dihydrofolic acid
- ENZYMATIC REDUCTION OF FOLIC ACID AND DIHYDROFOLIC ACID TO TETRAHYDROFOLIC ACID (Journal of Biological Chemistry, 1957)
- Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates (Proceedings of the National Academy of Sciences of the United States of America, 1985)
- Enzymatic Reduction of Dihydrofolic Acid (Journal of Biological Chemistry, 1958)
- Acidic dissociation constants of folic acid, dihydrofolic acid, and methotrexate. (Journal of Biological Chemistry, 1977)
- THE BIOSYNTHESIS OF FOLIC ACID. III. ENZYMATIC FORMATION OF DIHYDROFOLIC ACID FROM DIHYDROPTEROIC ACID AND OF TETRAHYDROPTEROYLPOLYGLUTAMIC ACID COMPOUNDS FROM TETRAHYDROFOLIC ACID. (Journal of Biological Chemistry, 1964)
- The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase (Gene, 1983)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1C(=NC2=C(N1)NC(=NC2=O)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
-
InChIKeyOZRNSSUDZOLUSN-UHFFFAOYSA-N
- Pubchem - Dihydrofolic acid
- Wikipedia - 7,8-dihydrofolic acid
Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase. Since tetrahydrofolate is needed to make both purines and pyrimidines, which are building blocks of DNA and RNA, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis.
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Dihydrofolic acid
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