| Weight | 480.561 g/mol |
|---|---|
| Formula | C27H32N2O6 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Solifenacin succinate (242478-38-2, 242478-37-1)
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- A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trial. (European Urology, 2005)
- RANDOMIZED, DOUBLE-BLIND PLACEBO CONTROLLED TRIAL OF THE ONCE DAILY ANTIMUSCARINIC AGENT SOLIFENACIN SUCCINATE IN PATIENTS WITH OVERACTIVE BLADDER (The Journal of Urology, 2004)
- In vitro and in vivo tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats (European Journal of Pharmacology, 2004)
- Pharmacological Characterization of a New Antimuscarinic Agent, Solifenacin Succinate, in Comparison with Other Antimuscarinic Agents (Biological & Pharmaceutical Bulletin, 2007)
- Comparison of in vitro selectivity profiles of solifenacin succinate (YM905) and current antimuscarinic drugs in bladder and salivary glands: a Ca2+ mobilization study in monkey cells. (Life Sciences, 2004)
- Muscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in mice. (British Journal of Pharmacology, 2005)
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- Pubchem - Solifenacin succinate
- Wikipedia - solifenacin succinate
Solifenacin (INN, trade name Vesicare) is a medicine of the antimuscarinic class and was developed for treating contraction of overactive bladder with associated problems such as increased urination frequency and urge incontinence. It is manufactured and marketed by Astellas, GlaxoSmithKline and Teva Pharmaceutical Industries.
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Synthesis
(R)-Quinuclidin-3-yl chloroformate
+
1-Phenyl-1,2,3,4-tetrahydroisoquinoline
(Schotten-Baumann amide from acid)
benzene
+
Reactant
(Friedel-Crafts alkylation)
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Solifenacin succinate
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