| Weight | 638.832 g/mol |
|---|---|
| Formula | C27H31Br2ClN4O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 3 |
Lonafarnib (193275-84-2)
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- Sigma-Aldrich - Lonafarnib99.00 - 399.00 USD
- Fisher Scientific - Search for Lonafarnib
- TCI - Search for Lonafarnib
- The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) Inhibits Rheb Farnesylation and mTOR Signaling ROLE IN FTI ENHANCEMENT OF TAXANE AND TAMOXIFEN ANTI-TUMOR ACTIVITY (Journal of Biological Chemistry, 2005)
- The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase (Cancer Research, 2005)
- Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung carcinoma (Cancer, 2005)
- Phase I Study of the Farnesyltransferase Inhibitor Lonafarnib with Paclitaxel in Solid Tumors (Clinical Cancer Research, 2004)
- Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro. (Leukemia, 2005)
- The combination of the Farnesyl transferase inhibitor (Lonafarnib) and the proteasome inhibitor (Bortezomib) induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT (Blood, 2005)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N
-
InChIKeyDHMTURDWPRKSOA-UHFFFAOYSA-N
- Pubchem - Lonafarnib
- Wikipedia - 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide
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