| Weight | 410.404 g/mol |
|---|---|
| Formula | C16H31N2O8P |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 5 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 7 |
Oseltamivir phosphate (204255-11-8)
Score:
#167 in Microbiology
,
#620 in Biochemistry
,
#1789 in Biology
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#2129 in Chemistry
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- The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo. (Antiviral Research, 2002)
- Synthetic Approaches to the Neuraminidase Inhibitors Zanamivir (Relenza) and Oseltamivir Phosphate (Tamiflu) for the Treatment of Influenza (Chemical Reviews, 2009)
- The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A:Hong Kong:156:97 (H5N1) and A:Hong Kong:1074:99 (H9N2) influenza viruses (Antiviral Research, 2000)
- Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). (Drug Metabolism and Disposition, 2009)
- New, Azide-Free Transformation of Epoxides into 1,2-Diamino Compounds: Synthesis of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu) (Journal of Organic Chemistry, 2001)
- Synthetic Strategies for Oseltamivir Phosphate (European Journal of Organic Chemistry, 2008)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC.OP(=O)(O)O
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InChIKeyPGZUMBJQJWIWGJ-UHFFFAOYSA-N
- Pubchem - Oseltamivir phosphate
- Wikipedia - oseltamivir phosphate
Oseltamivir, sold under the brand name Tamiflu, is an antiviral medication used to treat and prevent influenza A and influenza B (flu). Many medical organizations recommend it in people who have complications or are at high risk of complications within 48 hours of first symptoms of infection. They recommend it to prevent infection in those at high-risk, but not the general population.
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Oseltamivir phosphate
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