Carbenicillin disodium (4800-94-6)

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  5 g
  $35.00

  25 g
  $131.00

Most-cited Publications

• Empiric Therapy with Carbenicillin and Gentamicin for Febrile Patients with Cancer and Granulocytopenia (The New England Journal of Medicine, 1971)
• AEROSOL CARBENICILLIN AND GENTAMICIN TREATMENT OF PSEUDOMONAS AERUGINOSA INFECTION IN PATIENTS WITH CYSTIC FIBROSIS (The Lancet, 1981)
• A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients. (The American Journal of Medicine, 1979)
• Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid form to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro (Journal of Antimicrobial Chemotherapy, 1978)
• SENSITIVITY OF PSEUDOMONAS RUGINOSA TO ANTIBIOTICS: EMERGENCE OF STRAINS HIGHLY RESISTANT TO CARBENICILLIN (The Lancet, 1969)
• The hemostatic defect produced by carbenicillin. (The New England Journal of Medicine, 1974)

Areas of Application

Safety

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Trends

Alternate Names

• Carbenicillin
• Geopen
• Pyopen
• Carboxybenzyl Penicillin
• CSL Brand of Carbenicillin Disodium Salt
• Carbecin
• Sanfer Brand of Carbenicillin Disodium Salt
• Microcillin
• Anabactyl
• Carbapen
• SMILES
  CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)C(=O)[O-])C(=O)[O-])C.[Na+].[Na+]
• InChIKey
  RTYJTGSCYUUYAL-UHFFFAOYSA-L

External Links

• Pubchem - Carbenicillin disodium
• Wikipedia - carbenicillin disodium
  Carbenicillin is a bactericidal antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It was discovered by scientists at Beecham and marketed as Pyopen. It has Gram-negative coverage which includes Pseudomonas aeruginosa but limited Gram-positive coverage.

Synthesis

Reactant  +  (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate (Schotten-Baumann amide from acid)

Synthesis of Carbenicillin disodium ›

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