| Weight | 255.745 g/mol |
|---|---|
| Formula | C13H18ClNO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 4 |
Alaproclate (60719-82-6)
alaproclate hydrochloride, (D)-isomer · A 23189 · alaproclate hydrochloride
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- Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia (Journal of Neural Transmission, 1980)
- Role of serotonin in memory: facilitation by alaproclate and zimeldine (Psychopharmacology, 1984)
- Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia (Journal of Neural Transmission, 1984)
- Comparison of Desipramine, Amitriptyline, Zimeldine and Alaproclate in Six Animal Models Used to Investigate Antidepressant Drugs (Pharmacology & Toxicology, 1988)
- A doubleblind comparison of alaproclate and placebo in the treatment of patients with senile dementia (Acta Psychiatrica Scandinavica, 1985)
- Effects of subchronic treatment with imipramine, zimelidine and alaproclate on regional tissue levels of substance P-and neurokinin a/neurokinin B-like immunoreactivity in the brain and spinal cord of the rat (Neuropharmacology, 1987)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - alaproclate hydrochloride, (D)-isomer
- A 23189
- alaproclate hydrochloride
- A-23189
- alaproclate hydrochloride, (L)-isomer
- 2-aminopropionic acid-1-(4-chlorophenyl)-2-methyl-2-propyl ester.HCl
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SMILESCC(C(=O)OC(C)(C)CC1=CC=C(C=C1)Cl)N
-
InChIKeyFZSPJBYOKQPKCD-UHFFFAOYSA-N
- Pubchem - Alaproclate
- Wikipedia - alaproclate
Alaproclate (developmental code name GEA-654) is a drug that was being developed as an antidepressant by the Swedish pharmaceutical company Astra AB (now AstraZeneca) in the 1970s. It acts as a selective serotonin reuptake inhibitor (SSRI), and along with zimelidine and indalpine, was one of the first of its kind. Development was discontinued due to the observation of liver complications in rodent studies.
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Synthesis
L-alanine
+
Reactant
(Ester from carboxilic acid(SN2))
CHLOROBENZENE
+
Reactant
(Friedel-Crafts alkylation)
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