| Weight | 440.42 g/mol |
|---|---|
| Formula | C19H20N8O5 |
| Hydrogen Acceptors | 10 |
| Hydrogen Donors | 6 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 9 |
aminopterin (54-62-6)
Disodium Salt Aminopterin · Aminopterin Sodium
Score:
#807 in Biochemistry
,
#2182 in Biology
,
#2686 in Chemistry
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- Sigma-Aldrich - aminopterin61.20 - 417.00 USD
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- TCI - aminopterin99.00 - 297.00 USD
- Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin) (The New England Journal of Medicine, 1948)
- Therapeutic suppression of tissue reactivity. II. Effect of aminopterin in rheumatoid arthritis and psoriasis. (The American Journal of the Medical Sciences, 1951)
- New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties (Cancer Chemotherapy and Pharmacology, 1984)
- New folate analogs of the 10-deaza-aminopterin series: further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models (Cancer Chemotherapy and Pharmacology, 1984)
- Inhibition of dihydrofolic reductase by aminopterin and amethopterin. (Experimental Biology and Medicine, 1958)
- Attempted abortion with aminopterin (4-amino-pteroylglutamic acid); malformations of the child. (JAMA Pediatrics, 1959)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Disodium Salt Aminopterin
- Aminopterin Sodium
-
SMILESC1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N
-
InChIKeyTVZGACDUOSZQKY-UHFFFAOYSA-N
- Pubchem - aminopterin
- Wikipedia - aminopterin
Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase.
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