Bromisoval (496-67-3)

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Suppliers

• Sigma-Aldrich - Bromisoval
  51.50 USD
• Fisher Scientific - Search for Bromisoval
• TCI - Bromisoval
  37.00 USD

Most-cited Publications

• New bromisoval (bromural) metabolites in human urine: a-(cystein-S-yl)isovalerylurea, a-(N-acetylcystein-S-yl)isovalerylurea and a-(cysteamin-S-yl)isovaleric acid (Journal of Chromatography A, 1978)
• Detection of Bromisovalum from the Bone Marrow of Skeletonized Human Remains: A Case Report with a Comparison between Gas Chromatography/Mass Spectrometry (GC/MS) and High-Performance Liquid Chromatography/Mass Spectrometry (LC/MS) (Medicine Science and The Law, 1997)
• Gerichtstoxikologische Identifizierung von Bromisoval, Karbromal und ihren Entbromungsprodukten unter Verwendung von Infrarotspektroskopie und Dnnschichtchromatographie (Archives of Toxicology, 1962)
• Rapid Isolation with Sep-Pak C18 Cartridges and Wide-Bore Capillary Gas Chromatography of Bromisovalum (Journal of Analytical Toxicology, 1992)
• Sensitive and selective determination of bromisovalum by high-performance liquid chromatography/particle beam mass spectrometry (Forensic Science International, 1995)
• The determination of bromisoval and carbromal in biological material (Journal of Pharmacy and Pharmacology, 1969)

Safety

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Trends

Alternate Names

• Bromisovalum
• Sedes A
• Bromoisovalerylurea
• Bromyl
• Bromvaleton
• (alpha-Bromoisovaleryl)urea
• Bromovalerylurea
• Bromovalcarbamide
• SMILES
  CC(C)C(C(=O)NC(=O)N)Br
• InChIKey
  CMCCHHWTTBEZNM-UHFFFAOYSA-N

External Links

• Pubchem - Bromisoval
• Wikipedia - bromisoval
  Bromisoval (INN), commonly known as bromovalerylurea, is a hypnotic and sedative of the bromoureide group discovered by Knoll in 1907 and patented in 1909. It is marketed over the counter in Asia under various trade names (such as Brovarin), usually in combination with nonsteroidal anti-inflammatory drugs. Chronic use of bromisoval has been associated with bromine poisoning.

Synthesis

Isocyanic acid  +  2-bromo-3-methylbutanamide (Thiourea)

ISOVALERYLUREA  +  N-Bromosuccinimide (Wohl-Ziegler reaction)

2-bromo-3-methylbutanoyl chloride  +  urea (Schotten-Baumann amide from acid)

Reactant  +  CARBON TETRACHLORIDE (Appel reaction)

Reactant  +  dimethyl sulfide (Corey-Kim oxidation of secondary alcohols)

Synthesis of Bromisoval ›

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