| Weight | 348.358 g/mol |
|---|---|
| Formula | C20H16N2O4 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 1 |
camptothecin (7689-03-4)
Score:
#1195 in Biochemistry
,
#3016 in Biology
,
#3769 in Chemistry
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- Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I (Journal of Biological Chemistry, 1985)
- PLANT ANTITUMOR AGENT I. THE ISOLATION AND STRUCTURE OF CAMPTOTHECIN, A NOVEL ALKALOIDAL LEUKEMIA AND TUMOR INHIBITOR FROM CAMPTOTHECA ACUMINATA (Journal of the American Chemical Society, 1966)
- Arrest of Replication Forks by Drug-stabilized Topoisomerase I-DNA Cleavable Complexes as a Mechanism of Cell Killing by Camptothecin (Cancer Research, 1989)
- Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note (Cancer Research, 1989)
- Identification of Mammalian DNA Topoisomerase I as an Intracellular Target of the Anticancer Drug Camptothecin (Cancer Research, 1988)
- Intracellular Roles of SN-38, a Metabolite of the Camptothecin Derivative CPT-11, in the Antitumor Effect of CPT-11 (Cancer Research, 1991)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
-
InChIKeyVSJKWCGYPAHWDS-UHFFFAOYSA-N
- Pubchem - camptothecin
- Wikipedia - camptothecin
Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E.
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camptothecin
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