| Weight | 381.379 g/mol |
|---|---|
| Formula | C17H14F3N3O2S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 3 |
celecoxib (169590-42-5)
Celebrex · SC58635 · SC-58635
Score:
#251 in Neuroscience
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#316 in Biochemistry
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#1155 in Biology
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#1318 in Chemistry
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- Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis The CLASS Study: A Randomized Controlled Trial (JAMA, 2000)
- THE EFFECT OF CELECOXIB, A CYCLOOXYGENASE-2 INHIBITOR, IN FAMILIAL ADENOMATOUS POLYPOSIS (The New England Journal of Medicine, 2000)
- Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention (The New England Journal of Medicine, 2005)
- Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). (Journal of Medicinal Chemistry, 1997)
- Chemopreventive Activity of Celecoxib, a Specific Cyclooxygenase-2 Inhibitor, against Colon Carcinogenesis (Cancer Research, 1998)
- Celecoxib for the prevention of sporadic colorectal adenomas (The New England Journal of Medicine, 2006)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Celebrex
- SC58635
- SC-58635
- 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
- SC 58635
-
SMILESCC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F
-
InChIKeyRZEKVGVHFLEQIL-UHFFFAOYSA-N
- Pubchem - celecoxib
- Wikipedia - celecoxib
Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in people two years or older. Side effects include a 37% increase in incidence of major vascular events, which include nonfatal myocardial infarction, nonfatal stroke, or death from a blood vessel-related cause.
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