| Weight | 216.284 g/mol |
|---|---|
| Formula | C13H16N2O |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 4 |
cirazoline (59939-16-1)
LD-3098 · cirazoline monohydrochloride · 2-(2'-cyclopropylphenoxymethyl)imidazoline hydrochloride
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- Further Characterization of the Guinea Pig Cerebral Cortex Idazoxan Receptor: Solubilization, Distinction from the Imidazole Site, and Demonstration of Cirazoline as an Idazoxan Receptor-Selective Drug (Journal of Neurochemistry, 1990)
- The alpha-1 adrenergic agonist, cirazoline, impairs spatial working memory performance in aged monkeys (Pharmacology, Biochemistry and Behavior, 1997)
- Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist. (Journal of Pharmacology and Experimental Therapeutics, 1982)
- Stimulatory effects of clonidine, cirazoline and rilmenidine on locus coeruleus noradrenergic neurones: possible involvement of imidazoline-preferring receptors. (Naunyn-schmiedebergs Archives of Pharmacology, 1993)
- Reversal of cirazoline- and phenylpropanolamine-induced anorexia by the 1-receptor antagonist prazosin (Pharmacology, Biochemistry and Behavior, 1992)
- Alpha-adrenergic potentiation of beta-adrenergic stimulation of rat pineal N-acetyltransferase. Studies using cirazoline and fluorine analogs of norepinephrine. (Biochemical Pharmacology, 1984)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - LD-3098
- cirazoline monohydrochloride
- 2-(2'-cyclopropylphenoxymethyl)imidazoline hydrochloride
- LD 3098
-
SMILESC1CC1C2=CC=CC=C2OCC3=NCCN3
-
InChIKeyYAORIDZYZDUZCM-UHFFFAOYSA-N
- Pubchem - cirazoline
- Wikipedia - cirazoline
Cirazoline is a full agonist at the 1A adrenergic receptor, a partial agonist at both the 1B and 1D adrenergic receptors, and a nonselective antagonist to the 2 adrenergic receptor. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent. Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of 1 adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.
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Synthesis
Reactant
+
Chlorocyclopropane
(Friedel-Crafts alkylation)
Reactant
+
2-(CHLOROMETHYL)-2-IMIDAZOLINE
(Williamson ether)
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