| Weight | 329.407 g/mol |
|---|---|
| Formula | C20H19N5 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 4 |
Dapivirine (244767-67-7)
Score:
#2 in HIV/AIDS
,
#18 in Virology
,
#467 in Microbiology
,
#3712 in Biology
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- Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women. (Journal of Acquired Immune Deficiency Syndromes, 2009)
- Safety and Availability of Dapivirine (TMC120) Delivered from an Intravaginal Ring (AIDS Research and Human Retroviruses, 2009)
- Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir. (European Journal of Pharmaceutical Sciences, 2010)
- Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women. (The New England Journal of Medicine, 2016)
- Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1 (Journal of Pharmaceutical Sciences, 2008)
- Inhibition of Human Immunodeficiency Virus Type 1 Infection by the Candidate Microbicide Dapivirine, a Nonnucleoside Reverse Transcriptase Inhibitor (Antimicrobial Agents and Chemotherapy, 2009)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C
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- Pubchem - Dapivirine
- Wikipedia - dapivirine
Dapivirine (TMC120) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) developed at Janssen Therapeutics (formerly Tibotec Therapeutics). The International Partnership for Microbicides (IPM) has held exclusive worldwide rights to dapivirine since 2014, building upon a 2004 royalty-free license to develop dapivirine-based microbicides for women in resource-poor countries. A monthly intravaginal ring containing dapivirine has been developed as a form of HIV prevention for women.
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