| Weight | 228.208 g/mol |
|---|---|
| Formula | C8H12N4O4 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
Decitabine (2353-33-5)
Dacogen · 5-deoxyazacytidine · 2'-deoxy-5-azacytidine
Score:
#883 in Biochemistry
,
#2357 in Biology
,
#2921 in Chemistry
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- Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study (Cancer, 2006)
- Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2-deoxycytidine (decitabine) in hematopoietic malignancies (Blood, 2004)
- Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia (Blood, 2007)
- Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2-deoxycytidine (decitabine) treatment (Blood, 2002)
- Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia (Journal of Clinical Oncology, 2012)
- Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine (International Journal of Cancer, 2008)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Dacogen
- 5-deoxyazacytidine
- 2'-deoxy-5-azacytidine
- AzadC compound
- 5-azadeoxycytidine
- NSC-127716
- NSC 127716
- decitabine mesylate
- 5-aza-2'-deoxycytidine
-
SMILESC1C(C(OC1N2C=NC(=NC2=O)N)CO)O
-
InChIKeyXAUDJQYHKZQPEU-UHFFFAOYSA-N
- Pubchem - Decitabine
- Wikipedia - decitabine
Decitabine (trade name Dacogen), or 5-aza-2'-deoxycytidine, acts as an Nucleic Acid Synthesis Inhibitor. It is a drug for the treatment of myelodysplastic syndromes, a class of conditions where certain blood cells are dysfunctional, and for acute myeloid leukemia (AML). Chemically, it is a cytidine analog.
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Decitabine
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