| Weight | 230.676 g/mol |
|---|---|
| Formula | C8H7ClN2O2S |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 0 |
diazoxide (364-98-7)
Hyperstat · Proglycem
Score:
#499 in Neuroscience
,
#869 in Biochemistry
,
#2325 in Biology
,
#2877 in Chemistry
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- Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K+ Channels Possible Mechanism of Cardioprotection (Circulation Research, 1997)
- Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic -cells (Pflgers Archiv: European Journal of Physiology, 1986)
- Diazoxide-Induced Cardioprotection Requires Signaling Through a Redox-Sensitive Mechanism (Circulation Research, 2001)
- The essential role of the Walker A motifs of SUR1 in KATP channel activation by MgADP and diazoxide (The EMBO Journal, 1997)
- KATP channelindependent targets of diazoxide and 5hydroxydecanoate in the heart (The Journal of Physiology, 2002)
- Suppression of Serum Insulin by Diazoxide Reduces Serum Testosterone Levels in Obese Women with Polycystic Ovary Syndrome (The Journal of Clinical Endocrinology and Metabolism, 1989)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Hyperstat
- Proglycem
-
SMILESCC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl
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InChIKeyGDLBFKVLRPITMI-UHFFFAOYSA-N
- Pubchem - diazoxide
- Wikipedia - diazoxide
Diazoxide (INN; brand name Proglycem) is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels, preventing calcium flux across the sarcolemma and activation of the contractile apparatus. In the United States, this agent is only available in the oral form and is typically given in hospital settings.
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