| Weight | 188.182 g/mol |
|---|---|
| Formula | C11H8O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 0 |
Plumbagin (481-42-5)
2-methyl-5-hydroxy-1,4-naphthoquinone · 5-hydroxy-2-methyl-1,4-naphthoquinone
Score:
#1931 in Biochemistry
,
#4102 in Biology
,
#5169 in Chemistry
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- Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Suppresses NF-B Activation and NF-B-regulated Gene Products Through Modulation of p65 and IB Kinase Activation, Leading to Potentiation of Apoptosis Induced by Cytokine and Chemotherapeutic Agents (Journal of Biological Chemistry, 2006)
- Cytotoxic Action of Juglone and Plumbagin: A Mechanistic Study Using HaCaT Keratinocytes (Chemical Research in Toxicology, 2004)
- Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells (Molecular Cancer Therapeutics, 2006)
- Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo (Journal of Pharmacology and Experimental Therapeutics, 2006)
- Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells (Cancer Letters, 2008)
- Plumbagin: a study of its anticancer, antibacterial and antifungal properties. (Indian Journal of Experimental Biology, 1980)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 2-methyl-5-hydroxy-1,4-naphthoquinone
- 5-hydroxy-2-methyl-1,4-naphthoquinone
-
SMILESCC1=CC(=O)C2=C(C1=O)C=CC=C2O
-
InChIKeyVCMMXZQDRFWYSE-UHFFFAOYSA-N
- Pubchem - Plumbagin
- Wikipedia - plumbagin
Plumbagin or 5-hydroxy-2-methyl-1,4-naphthoquinone is an organic compound with the chemical formula C 11H 8O 3. It is regarded as a toxin and it is genotoxic and mutagenic. Plumbagin is a yellow dye, formally derived from naphthoquinone.
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Plumbagin
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