| Weight | 441.575 g/mol |
|---|---|
| Formula | C19H27N3O5S2 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 11 |
Dofetilide (115256-11-6)
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- Sigma-Aldrich - Dofetilide111.00 - 445.50 USD
- Fisher Scientific - Search for Dofetilide
- TCI - Search for Dofetilide
- Dofetilide in patients with congestive heart failure and left ventricular dysfunction (The New England Journal of Medicine, 1999)
- Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. (Circulation Research, 1993)
- Efficacy of Dofetilide in the Treatment of Atrial Fibrillation-Flutter in Patients With Reduced Left Ventricular Function A Danish Investigations of Arrhythmia and Mortality ON Dofetilide (DIAMOND) Substudy (Circulation, 2001)
- Efficacy and Safety of Oral Dofetilide in Converting to and Maintaining Sinus Rhythm in Patients With Chronic Atrial Fibrillation or Atrial Flutter The Symptomatic Atrial Fibrillation Investigative Research on Dofetilide (SAFIRE-D) Study (Circulation, 2000)
- Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide. (Journal of Pharmacology and Experimental Therapeutics, 1992)
- Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction : a randomised trial (The Lancet, 2000)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
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InChIKeyIXTMWRCNAAVVAI-UHFFFAOYSA-N
- Pubchem - Dofetilide
- Wikipedia - dofetilide
Dofetilide is a class III antiarrhythmic agent. It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 g of dofetilide. It is not available in Europe or Australia.
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Synthesis
N-(4-hydroxyphenyl)methanesulfonamide
+
Reactant
(Williamson ether)
N-Phenylmethanesulfonamide
+
Reactant
(Friedel-Crafts alkylation)
Similar Compounds
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Dofetilide
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