| Weight | 276.679 g/mol |
|---|---|
| Formula | C13H9ClN2O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 3 |
GW9662 (22978-25-2)
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- Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662 (Biochemistry, 2002)
- GW9662, a potent antagonist of PPAR, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPAR agonist rosiglitazone, independently of PPAR activation (British Journal of Pharmacology, 2004)
- The selective PPAR antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion (Kidney International, 2005)
- Peroxisome proliferator-activated receptor- antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia (Critical Care Medicine, 2006)
- PPAR- Agonist GW1929 But Not Antagonist GW9662 Reduces TBBPA-Induced Neurotoxicity in Primary Neocortical Cells (Neurotoxicity Research, 2014)
- The PPAR- antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR- in human macrophage polarization (Journal of Inflammation, 2015)
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SMILESC1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl
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InChIKeyDNTSIBUQMRRYIU-UHFFFAOYSA-N
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GW9662
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