| Weight | 354.472 g/mol |
|---|---|
| Formula | C17H26N2O4S |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 7 |
Sultopride (53583-79-2)
Solian · amisulpride · DAN 2163
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#171 in Neurology
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- Neurochemical Characteristics of Amisulpride, an Atypical Dopamine D2/D3 Receptor Antagonist with Both Presynaptic and Limbic Selectivity (Journal of Pharmacology and Experimental Therapeutics, 1997)
- Amisulpride, an unusual "atypical" antipsychotic: a meta-analysis of randomized controlled trials. (American Journal of Psychiatry, 2002)
- Psychopharmacological Profile of Amisulpride: An Antipsychotic Drug with Presynaptic D2/D3 Dopamine Receptor Antagonist Activity and Limbic Selectivity (Journal of Pharmacology and Experimental Therapeutics, 1997)
- Treatment of negative symptoms in schizophrenia with amisulpride. (British Journal of Psychiatry, 1995)
- Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo (Psychopharmacology, 2009)
- Celecoxib treatment in an early stage of schizophrenia: Results of a randomized, double-blind, placebo-controlled trial of celecoxib augmentation of amisulpride treatment (Schizophrenia Research, 2010)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Solian
- amisulpride
- DAN 2163
- N-(ethyl-1-pyrrolidinyl- 2-methyl)methoxy-2-ethylsulfonyl-5-benzamide
- LIN 1418
- sultopride hydrochloride
- Barnetil
-
SMILESCCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)CC)OC
-
InChIKeyUNRHXEPDKXPRTM-UHFFFAOYSA-N
- Pubchem - Sultopride
- Wikipedia - sultopride
Sultopride (trade names Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia. It was launched by Sanofi-Aventis in 1976. Sultopride acts as a selective D2 and D3 receptor antagonist.
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Synthesis
5-Ethylsulfonyl-2-methoxybenzoyl chloride
+
2-(Aminomethyl)-1-ethylpyrrolidine
(Schotten-Baumann amide from acid)
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