Sotalol hydrochloride (959-24-0)

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Suppliers

• Sigma-Aldrich - Sotalol hydrochloride
  80.20 - 396.90 USD
• Fisher Scientific - Search for Sotalol hydrochloride
• TCI - Search for Sotalol hydrochloride

Most-cited Publications

• Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction (The Lancet, 1996)
• Amiodarone versus Sotalol for Atrial Fibrillation (The New England Journal of Medicine, 2005)
• Comparison of -Blockers, Amiodarone Plus -Blockers, or Sotalol for Prevention of Shocks From Implantable Cardioverter Defibrillators: The OPTIC Study: A Randomized Trial (JAMA, 2006)
• CONTROLLED TRIAL OF SOTALOL FOR ONE YEAR AFTER MYOCARDIAL INFARCTION (The Lancet, 1982)
• Sex Difference in Risk of Torsade de Pointes With d,l-Sotalol (Circulation, 1996)
• Prevention of Implantable-Defibrillator Shocks by Treatment with Sotalol (The New England Journal of Medicine, 1999)

Areas of Application

Safety

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Trends

Alternate Names

• Sotalol
• Darob
• MJ 1999
• Sotalol Monohydrochloride
• MJ1999
• MJ-1999
• SMILES
  CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl
• InChIKey
  VIDRYROWYFWGSY-UHFFFAOYSA-N

External Links

• Pubchem - Sotalol hydrochloride
• Wikipedia - sotalol hydrochloride
  Sotalol is a medication used to treat abnormal heart rhythms. The U.S. Food and Drug Administration (FDA) advises that sotalol only be used for serious abnormal heart rhythms, because its prolongation of the QT interval carries a small risk of life-threatening polymorphic ventricular tachycardia known as torsade de pointes.

Synthesis

2-(Propan-2-ylamino)acetaldehyde  +  N-(4-chlorophenyl)methanesulfonamide (Grignard alcohol)

Methanesulfonyl chloride  +  Reactant (Sulfonamide)

Reactant  +  ISOPROPYLAMINE (Reductive amination)

Reactant  +  2-CHLOROPROPANE (Alkylation of primary amines)

N-Phenylmethanesulfonamide  +  Reactant (Friedel-Crafts alkylation)

Synthesis of Sotalol hydrochloride ›

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Sotalol hydrochloride

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