idarubicin hydrochloride (57852-57-0)

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Suppliers

• Sigma-Aldrich - Search for idarubicin hydrochloride
• Fisher Scientific - Search for idarubicin hydrochloride
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Most-cited Publications

• Molecular Remission in PML/RAR-Positive Acute Promyelocytic Leukemia by Combined All-trans Retinoic Acid and Idarubicin (AIDA) Therapy (Blood, 1997)
• Cytarabine Plus Idarubicin or Daunorubicin as Induction and Consolidation Therapy for Previously Untreated Adult Patients With Acute Myeloid Leukemia (Blood, 1992)
• Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia (Blood, 1991)
• A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: a Southeastern Cancer Study Group Study. (Journal of Clinical Oncology, 1992)
• Phase I/II Study of Combination Therapy With Sorafenib, Idarubicin, and Cytarabine in Younger Patients With Acute Myeloid Leukemia (Journal of Clinical Oncology, 2010)
• Randomized Phase II Study of Fludarabine + Cytosine Arabinoside + Idarubicin All-Trans Retinoic Acid Granulocyte Colony-Stimulating Factor in Poor Prognosis Newly Diagnosed Acute Myeloid Leukemia and Myelodysplastic Syndrome (Blood, 1999)

Areas of Application

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Trends

Alternate Names

• Idarubicin
• IMI30
• 4-Demethoxydaunorubicin
• IMI 30
• 4-Desmethoxydaunorubicin
• 4 Desmethoxydaunorubicin
• NSC256439
• NSC 256439
• 4 Demethoxydaunorubicin
• IMI-30
• NSC-256439
• SMILES
  CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl
• InChIKey
  JVHPTYWUBOQMBP-UHFFFAOYSA-N

External Links

• Pubchem - idarubicin hydrochloride
• Wikipedia - idarubicin hydrochloride
  Idarubicin or 4-demethoxydaunorubicin is an anthracycline antileukemic drug. It inserts itself into DNA and prevents DNA unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake.

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