| Weight | 482.54 g/mol |
|---|---|
| Formula | C28H26N4O4 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 2 |
7-Hydroxystaurosporine (112953-11-4)
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- The Radiosensitizing Agent 7-Hydroxystaurosporine (UCN-01) Inhibits the DNA Damage Checkpoint Kinase hChk1 (Cancer Research, 2000)
- Abrogation of an S-Phase Checkpoint and Potentiation of Camptothecin Cytotoxicity by 7-Hydroxystaurosporine (UCN-01) in Human Cancer Cell Lines, Possibly Influenced by p53 Function (Cancer Research, 1997)
- Enhancement of cisplatin-induced cytotoxicity by 7-Hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor (Clinical Cancer Research, 1996)
- Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). (Oncogene, 2002)
- Apoptotic response to camptothecin and 7hydroxystaurosporine (UCN01) in the 8 human breast cancer cell lines of the NCI anticancer drug screen: Multifactorial relationships with topoisomerase i, protein kinase C, Bcl2, p53, MDM2 and caspase pathways (International Journal of Cancer, 1999)
- S-Phase Arrest by Nucleoside Analogues and Abrogation of Survival without Cell Cycle Progression by 7-Hydroxystaurosporine (Cancer Research, 2001)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(NC6=O)O)NC)OC
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InChIKeyPBCZSGKMGDDXIJ-UHFFFAOYSA-N
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