| Weight | 411.63 g/mol |
|---|---|
| Formula | C27H41NO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 0 |
CYCLOPAMINE (4449-51-8)
Score:
#1577 in Biochemistry
,
#3619 in Biology
,
#4544 in Chemistry
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- Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened (Genes & Development, 2002)
- Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. (Nature, 2000)
- THE TERATOGENIC VERATRUM ALKALOID CYCLOPAMINE INHIBITS SONIC HEDGEHOG SIGNAL TRANSDUCTION (Development, 1998)
- Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma (Stem Cells, 2007)
- Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor (Proceedings of the National Academy of Sciences of the United States of America, 1998)
- Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment (International Journal of Cancer, 2004)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
-
InChIKeyQASFUMOKHFSJGL-UHFFFAOYSA-N
- Pubchem - CYCLOPAMINE
- Wikipedia - cyclopamine
Cyclopamine (11-deoxojervine) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia).
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