| Weight | 325.452 g/mol |
|---|---|
| Formula | C21H27NO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Ifenprodil (23210-56-2, 23210-58-4)
4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol · ifenprodil tartrate (2:1), (R-(R*,R*))-isomer · ifenprodil, (R*,S*)-(+-)-isomer
Score:
#800 in Neuroscience
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#3509 in Biology
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#4393 in Chemistry
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- Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. (Molecular Pharmacology, 1993)
- Developmental Changes in NMDA Receptor Glycine Affinity and Ifenprodil Sensitivity Reveal Three Distinct Populations of NMDA Receptors in Individual Rat Cortical Neurons (The Journal of Neuroscience, 1998)
- Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia. (Journal of Pharmacology and Experimental Therapeutics, 1988)
- Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. (Molecular Pharmacology, 1989)
- A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones. (The Journal of Physiology, 1996)
- Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties. (Journal of Pharmacology and Experimental Therapeutics, 1988)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol
- ifenprodil tartrate (2:1), (R-(R*,R*))-isomer
- ifenprodil, (R*,S*)-(+-)-isomer
- ifenprodil tartrate (1:1), (R-(R*,R*))-isomer
- 61 91 RC
- ifenprodil hydrochloride
- 2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-2-methyl-1-ethanol
- ifenprodil, tartrate(R-(R*,R*))-isomer
- ifenprodil hydrochloride, (+-)-isomer
- ifenprodil tartrate
- Vadilex
- ifenprodil tartrate (1:1), (R*,S*)-(+-)-(R-(R*,R*))-isomer
-
SMILESCC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3
-
InChIKeyUYNVMODNBIQBMV-UHFFFAOYSA-N
- Pubchem - Ifenprodil
- Wikipedia - ifenprodil
Ifenprodil is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, ifenprodil inhibits GIRK channels, and interacts with alpha1 adrenergic, serotonin, and sigma receptors. NMDA receptors are multimeric ionotropic glutamate receptors composed of four subunits.
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