| Weight | 357.793 g/mol |
|---|---|
| Formula | C19H16ClNO4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 4 |
Indomethacin (53-86-1)
Indocin · Indometacin · Indocid
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#8 in Neuroscience
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#47 in Biology
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#48 in Chemistry
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- Sigma-Aldrich - Indomethacin55.70 - 463.50 USD
- Fisher Scientific - Search for Indomethacin
- TCI - Search for Indomethacin
- Peroxisome Proliferator-activated Receptors and Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs (Journal of Biological Chemistry, 1997)
- Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration (Cell, 1995)
- Clinical trial of indomethacin in Alzheimer's disease (Neurology, 1993)
- Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions. (Pharmaceutical Research, 1997)
- Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen (Nature, 1971)
- Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. (The New England Journal of Medicine, 2001)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Indocin
- Indometacin
- Indocid
- Amuno
- Osmosin
- Indomet 140
- Metindol
- Indomethacin Hydrochloride
-
SMILESCC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
-
InChIKeyCGIGDMFJXJATDK-UHFFFAOYSA-N
- Pubchem - Indomethacin
- Wikipedia - indomethacin
Indometacin (INN; or USAN indomethacin) is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase, an enzyme that catalyzes the production of prostaglandins.
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Estimated Properties
| Boiling Point | 461.96 C | EPA T.E.S.T. |
|---|---|---|
| Density | 1.35 g/cm3 | EPA T.E.S.T. |
| Flash Point | 277.43 C | EPA T.E.S.T. |
| Water Solubility | 0.61 mg/L | EPA T.E.S.T. |
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Indomethacin
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