| Weight | 247.338 g/mol |
|---|---|
| Formula | C15H21NO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
Ketobemidone (469-79-4)
cetobemidon · 1-(4-(m-hydroxyphenyl)-1-methyl-4-piperidyl)-1-propanone · ketobemidone hydrochloride
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- Patient-controlled Analgesic Therapy, Part III: Pharmacokinetics and Analgesic Plasma Concentrations of Ketobemidone (Clinical Pharmacokinectics, 1982)
- Ketobemidone, methadone and pethidine are non-competitive N-methyl-d-aspartate (NMDA) antagonists in the rat cortex and spinal cord (Neuroscience Letters, 1995)
- Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem timeofflight mass spectrometry (Journal of Mass Spectrometry, 2002)
- Clinical pharmacokinetics and oral bioavailability of ketobemidone (European Journal of Clinical Pharmacology, 1980)
- A comparison between morphine, meperidine and ketobemidone in continuous intravenous infusion for postoperative relief. (Acta Anaesthesiologica Scandinavica, 1991)
- The opioid ketobemidone has a NMDA blocking effect. (Pain, 1996)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - cetobemidon
- 1-(4-(m-hydroxyphenyl)-1-methyl-4-piperidyl)-1-propanone
- ketobemidone hydrochloride
-
SMILESCCC(=O)C1(CCN(CC1)C)C2=CC(=CC=C2)O
-
InChIKeyALFGKMXHOUSVAD-UHFFFAOYSA-N
- Pubchem - Ketobemidone
- Wikipedia - ketobemidone
Ketobemidone, sold under the brand name Ketogan among others, is a powerful opioid painkiller. Its effectiveness against pain is in the same range as morphine, and it also has some NMDA-antagonist properties imparted, in part, by its metabolite norketobemidone. This may make it useful for some types of pain that do not respond well to other opioids.
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Synthesis
Phenol
+
Reactant
(Friedel-Crafts alkylation)
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