| Weight | 283.415 g/mol |
|---|---|
| Formula | C19H25NO |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
levallorphan (152-02-3)
Lorfan · Naloxiphan
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- THE RESPIRATORY, CIRCULATORY, AND NARCOTIC ANTAGONISTIC EFFECTS OF NALORPHINE, LEVALLORPHAN, AND NALOXONE IN ANAESTHETIZED SUBJECTS (Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 1969)
- Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey. (Journal of Pharmacology and Experimental Therapeutics, 1990)
- EFFECTS OF MORPHINE AND MEPERIDINE ON THE CENTRAL RESPIRATORY MECHANISMS IN THE CAT; THE ACTION OF LEVALLORPHAN IN ANTAGONIZING THESE EFFECTS (Journal of Pharmacology and Experimental Therapeutics, 1961)
- Lack of effect of levallorphan on analgesia induced by intraventricular application of porcine calcitonin in mice (European Journal of Pharmacology, 1979)
- Levallorphan methyl iodide (SR 58002), a potent narcotic antagonist with peripheral selectivity superior to that of other quaternary compounds (Life Sciences, 1983)
- Effect of naloxone or levallorphan on serum prolactin concentrations and apomorphine-induced growth hormone secretion. (Acta Psychiatrica Scandinavica, 1979)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Lorfan
- Naloxiphan
-
SMILESC=CCN1CCC23CCCCC2C1CC4=C3C=C(C=C4)O
-
InChIKeyOZYUPQUCAUTOBP-UHFFFAOYSA-N
- Pubchem - levallorphan
- Wikipedia - levallorphan
Levallorphan (INN, BAN) (brand names Lorfan, Naloxifan, Naloxiphan), also known as levallorphan tartrate (USAN), is an opioid modulator of the morphinan family used as an opioid analgesic and opioid antagonist/antidote. It acts as an antagonist of the -opioid receptor (MOR) and as an agonist of the -opioid receptor (KOR), and as a result, blocks the effects of stronger agents with greater intrinsic activity such as morphine whilst simultaneously producing analgesia. Levallorphan was formerly widely used in general anesthesia, mainly to reverse the respiratory depression produced by opioid analgesics and barbiturates used for induction of surgical anaesthesia whilst maintaining a degree of analgesia (via KOR agonism).
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