Score: #2040 in Biology , #2493 in Chemistry

  Alkene · Allyl compound · Analgesic · Cyclic compound · Cycloalkene · Cyclohexene · Dissociative drug · Drugs acting on the nervous system · Drugs by psychological effect · Kappa agonist · Opioid antagonist · Opioid receptor ligand · Opioid · Organic compound · Pharmaceutical · Psychoactive drug · Psychoactive drugs by mechanism of action · Semisynthetic opioid · Six-membered ring

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• Sigma-Aldrich - Search for Nalorphine
• Fisher Scientific - Search for Nalorphine
• TCI - Search for Nalorphine

Most-cited Publications

• The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. (Journal of Pharmacology and Experimental Therapeutics, 1976)
• BIOCHEMICAL AND PHARMACOLOGICAL CHANGES IN THE RAT FOLLOWING CHRONIC ADMINISTRATION OF MORPHINE, NALORPHINE AND NORMORPHINE (Journal of Pharmacology and Experimental Therapeutics, 1959)
• The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog. (Journal of Pharmacology and Experimental Therapeutics, 1976)
• Pharmacologic dissociation of behavior and EEG "sleep patterns" in dogs; morphine, n-allylnormorphine, and atropine. (Experimental Biology and Medicine, 1952)
• The analgesic effectiveness of nalorphine and nalorphine-morphine combinations in man. (Journal of Pharmacology and Experimental Therapeutics, 1954)
• N-ALLYLNORMORPHINE: EFFECTS OF SINGLE DOSES AND PRECIPITATION OF ACUTE "ABSTINENCE SYNDROMES" DURING ADDICTION TO MORPHINE, METHADONE OR HEROIN IN MAN (POST-ADDICTS) (Journal of Pharmacology and Experimental Therapeutics, 1953)

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Alternate Names

• Allylnormorphine
• Nalorphine Hydrochloride
• Lethidrone
• Nalorphine Hydrobromide
• Nalorphine, L-tartrate (1:1)
• Nalorphine, (14 alpha)-Isomer
• SMILES
  C=CCN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
• InChIKey
  UIQMVEYFGZJHCZ-UHFFFAOYSA-N

External Links

• Pubchem - Nalorphine
• Wikipedia - nalorphine
  Nalorphine (INN) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonistantagonist with opioid antagonist and analgesic properties. It was introduced in 1954 and was used as an antidote to reverse opioid overdose and in a challenge test to determine opioid dependence. It acts at two opioid receptors the -opioid receptor (MOR) where it has antagonistic effects, and at the -opioid receptor (KOR) (Ki = 1.6 nM; EC50 = 483 nM; Emax = 95%) where it exerts high-efficacy partial agonist/near-full agonist characteristics.

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