| Weight | 378.316 g/mol |
|---|---|
| Formula | C17H16F6N2O |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
mefloquine (53230-10-7, 49752-90-1)
Lariam · Mefloquine Hydrochloride · Ro215998001
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- Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. (The Lancet, 2004)
- Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study (The Lancet, 2000)
- Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. (Proceedings of the National Academy of Sciences of the United States of America, 1994)
- pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum (Molecular Microbiology, 2005)
- Decreasing pfmdr1 Copy Number in Plasmodium falciparum Malaria Heightens Susceptibility to Mefloquine, Lumefantrine, Halofantrine, Quinine, and Artemisinin (The Journal of Infectious Diseases, 2006)
- Potent block of Cx36 and Cx50 gap junction channels by mefloquine (Proceedings of the National Academy of Sciences of the United States of America, 2004)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Lariam
- Mefloquine Hydrochloride
- Ro215998001
- WR142,490
- Ro-21-5998-001
- WR 142,490
- Roche Brand of Mefloquine Hydrochloride
- Ro 21 5998 001
- Hoffmann La Roche Brand of Mefloquine Hydrochloride
- Hoffmann-La Roche Brand of Mefloquine Hydrochloride
- WR177,602
- WR-177,602
- Mephloquine
- WR 177,602
- WR-142,490
-
SMILESC1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O
-
InChIKeyXEEQGYMUWCZPDN-UHFFFAOYSA-N
- Pubchem - mefloquine
- Wikipedia - Mefloquine
Mefloquine, sold under the brand names Lariam among others, is a medication used to prevent or treat malaria. When used for prevention it is taken once a week and should be begun one or two weeks before potential exposure and continued for four weeks after potential exposure. It can be used to treat mild or moderate malaria but should not be used to treat severe malaria.
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