| Weight | 305.205 g/mol |
|---|---|
| Formula | C13H18Cl2N2O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 8 |
melphalan (1465-26-5, 148-82-3)
Alkeran · Phenylalanine Mustard · Sarcolysine
Score:
#113 in Biochemistry
,
#493 in Biology
,
#517 in Chemistry
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- Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. (The New England Journal of Medicine, 2008)
- Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial (The Lancet, 2006)
- Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 9906): a randomised trial (The Lancet, 2007)
- L-Phenylalanine Mustard (L-PAM) in the Management of Primary Breast Cancer (The New England Journal of Medicine, 1975)
- High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. (Journal of Clinical Oncology, 1992)
- Melphalan and purine analog-containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation (Blood, 2001)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H300: Fatal if swallowed
Danger Acute toxicity, oral - Category 1, 2 - H340: May cause genetic defects
Danger Germ cell mutagenicity - Category 1A, 1B - H360: May damage fertility or the unborn child
Danger Reproductive toxicity - Category 1A, 1B - H372: Causes damage to organs through prolonged or repeated exposure
Danger Specific target organ toxicity, repeated exposure - Category 1 - Alkeran
- Phenylalanine Mustard
- Sarcolysine
- L-PAM
- Sarkolysin
- Medphalan
- 4-(Bis(2-chloroethyl)amino)phenylalanine
- Merphalan
-
SMILESC1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl
-
InChIKeySGDBTWWWUNNDEQ-UHFFFAOYSA-N
- Pubchem - melphalan
- Wikipedia - melphalan
Melphalan (trade name Alkeran, in former USSR also known as Sarcolysin) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring.
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melphalan
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