| Weight | 247.338 g/mol |
|---|---|
| Formula | C15H21NO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
meperidine (57-42-1)
Demerol · Dolin · Pethidine
Score:
#19 in Neurology
,
#103 in Neuroscience
,
#540 in Biology
,
#573 in Chemistry
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- Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis (Science, 1983)
- The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. (Pain, 1977)
- Chronic parkinsonism secondary to intravenous injection of meperidine analogues (Psychiatry Research-neuroimaging, 1979)
- THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL) (Journal of Pharmacology and Experimental Therapeutics, 1944)
- Central nervous system excitatory effects of meperidine in cancer patients (Annals of Neurology, 1983)
- THE EFFECTS OF MORPHINE, METHADONE AND MEPERIDINE ON SOME REFLEX RESPONSES OF SPINAL ANIMALS TO NOCICEPTIVE STIMULATION (Journal of Pharmacology and Experimental Therapeutics, 1951)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Demerol
- Dolin
- Pethidine
- Meperidine Hydrochloride
- Dolantin
- Dolosal
- Dolargan
- Lydol
- Operidine EPJ-I
- Operidine EPJ I
- Dolsin
- Dolcontral
- Lidol
- Isonipecain
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SMILESCCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2
-
InChIKeyXADCESSVHJOZHK-UHFFFAOYSA-N
- Pubchem - meperidine
- Wikipedia - meperidine
Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class. Synthesized in 1939 as a potential anticholinergic agent by the German chemist Otto Eisleb, its analgesic properties were first recognized by Otto Schaumann while working for IG Farben, Germany. Pethidine is the prototype of a large family of analgesics including the pethidine 4-phenylpiperidines (piminodine, anileridine and others), the prodines (alphaprodine, MPPP, etc.), bemidones (ketobemidone, etc.) and others more distant, including diphenoxylate and analogues.
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Most-cited Publications
Areas of Application
Safety
Trends
Alternate Names
Estimated Properties
| Boiling Point | 282.54 C | EPA T.E.S.T. |
|---|---|---|
| Density | 1.06 g/cm3 | EPA T.E.S.T. |
| Flash Point | 136.56 C | EPA T.E.S.T. |
| Water Solubility | 711.56 mg/L | EPA T.E.S.T. |
External Links
Synthesis
benzene
+
Reactant
(Friedel-Crafts alkylation)
Similar Compounds
Pethidine hydrochloride
(50-13-5)
15 alternate names
3 suppliers
Ethyl 4-phenylpiperidine-4-carboxylate
(77-17-8)
15 alternate names
3 suppliers
Nisentil
(561-78-4)
15 alternate names
3 suppliers
77-83-8
(77-83-8, 19464-95-0)
15 alternate names
3 suppliers
Ethyl 3-phenylglycidate
(121-39-1)
15 alternate names
3 suppliers
Edifenphos
(17109-49-8)
15 alternate names
7 safety hazards
3 suppliers
p-Phenylacetanilide
(4075-79-0)
15 alternate names
3 suppliers
FENOXYCARB
(72490-01-8)
15 alternate names
2 safety hazards
3 suppliers
ISOPROPYLBIPHENYL
(19486-60-3, 25640-78-2)
15 alternate names
3 suppliers
Eticyclidine
(2201-15-2)
15 alternate names
3 suppliers
p-Isopropoxydiphenylamine
(101-73-5)
15 alternate names
3 suppliers
10094-34-5
(10094-34-5)
15 alternate names
3 suppliers
METHYLPHENIDATE HYDROCHLORIDE
(298-59-9)
15 alternate names
3 suppliers
DIPHENAMID
(957-51-7)
15 alternate names
1 safety hazard
3 suppliers
Diphenylmethane
(101-81-5)
15 alternate names
3 suppliers
101-72-4
(101-72-4)
15 alternate names
5 safety hazards
3 suppliers
N-Benzyl-N-ethylaniline
(92-59-1)
15 alternate names
3 suppliers
Focalin
(19262-68-1, 23655-65-4)
15 alternate names
3 suppliers
Iofendylate
(99-79-6)
15 alternate names
3 suppliers
DESMEDIPHAM
(13684-56-5)
15 alternate names
4 safety hazards
3 suppliers
4-METHOXYBIPHENYL
(613-37-6)
15 alternate names
3 suppliers
1,2-Diphenylethane
(103-29-7, 38888-98-1)
15 alternate names
3 suppliers
Dimethylbenzylcarbinyl acetate
(151-05-3)
15 alternate names
3 suppliers
methyl 2-(1H-indol-3-yl)acetate
(1912-33-0)
15 alternate names
3 suppliers
Carbaryl
(27636-33-5, 3197-92-0, 63-25-2)
15 alternate names
2 safety hazards
3 suppliers
Benzyl butyl phthalate
(85-68-7)
15 alternate names
4 safety hazards
3 suppliers
Biphenyl
(92-52-4, 68409-73-4)
15 alternate names
6 safety hazards
3 suppliers
Diphenyl oxide
(101-84-8)
15 alternate names
2 safety hazards
3 suppliers
1,2-DIPHENYLHYDRAZINE
(122-66-7, 38622-18-3)
15 alternate names
5 safety hazards
3 suppliers
Diphenylamine
(68442-68-2, 122-39-4)
15 alternate names
6 safety hazards
3 suppliers
Methyl yellow
(60-11-7)
15 alternate names
3 safety hazards
3 suppliers
trans-Stilbene
(103-30-0, 588-59-0)
15 alternate names
3 suppliers
Benzyl ether
(103-50-4)
15 alternate names
3 safety hazards
3 suppliers
Bisphenol B
(77-40-7)
15 alternate names
3 suppliers
Dibenzyl sulfide
(538-74-9)
15 alternate names
3 suppliers
DIPHENYL DISULFIDE
(882-33-7)
15 alternate names
2 safety hazards
3 suppliers
cis-Stilbene
(645-49-8)
15 alternate names
3 suppliers
DIBENAMINE
(51-50-3)
15 alternate names
3 suppliers
4-Acetamidofluorene
(28322-02-3)
15 alternate names
3 suppliers
Phenyl disulfide
(882-33-7)
15 alternate names
2 safety hazards
3 suppliers
methyl 2-benzamidoacetate
(1205-08-9)
15 alternate names
3 suppliers
530-44-9
(530-44-9)
15 alternate names
3 suppliers
Ethyl phenylpropiolate
(2216-94-6)
15 alternate names
3 suppliers
N,N'-Diphenylmethylenediamine
(101-77-9, 622-14-0)
15 alternate names
3 suppliers
2-Phenylphenol
(61788-42-9, 90-43-7)
15 alternate names
3 safety hazards
3 suppliers
DIETHYL PHTHALATE
(68988-18-1, 84-66-2)
15 alternate names
3 safety hazards
3 suppliers
Fonofos
(944-22-9, 62680-03-9)
15 alternate names
5 safety hazards
3 suppliers
2-Acetamidofluorene
(53-96-3)
15 alternate names
3 suppliers
azobenzene
(103-33-3, 17082-12-1, 1080-16-6)
15 alternate names
6 safety hazards
3 suppliers
Butylate
(2008-41-5)
15 alternate names
3 suppliers
TILETAMINE
(14176-49-9)
15 alternate names
3 suppliers
DIALLYL PHTHALATE
(131-17-9)
15 alternate names
4 safety hazards
3 suppliers
SIDURON
(1982-49-6)
15 alternate names
3 suppliers
DIBUTYL PHENYL PHOSPHATE
(2528-36-1)
15 alternate names
3 safety hazards
3 suppliers
meperidine
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